Smart and multifarious lab on a chip on paper

Smart and multifarious lab on a chip on paper

We present a showcase of devices developed in our research group exploiting (bio)sensor technologies which allow the design of ad hoc analytical tools combining several advantages including reduced time-to-result, automation, user-friendly, and simultaneous multi-analyte analysis. To deliver miniaturised and mass-produced (bio)sensors, printing techniques are one of the cross-cutting technologies to accomplish this issue. The recent vision of the sustainability has boosted the exploitation of smart supports including paper, in order to enhance their affordability, robustness, and reproducibility. We will show some office and filter paper-based lab on a chip applied for precision medicine, for evaluating polluted environmental samples and concrete artwork state, and for fast detection of biological and chemical warfare agent
Italy


Smart and multifarious lab on a chip on paper

Fabiana Arduini, Veronica Caratelli, Vincenzo Mazzaracchio, Noemi Colozza, Eleonora Marcoccio, Danila Moscone

Fabiana Arduini is Associate Professor at Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, Italy and in 2018 she has been elected Coordinator of Italian Sensor group, Analytical Chemistry Division of the Italian Chemical Society.
Her research activity deals with the development of Bioassay and Biosensor systems, Electrochemical (bio)sensors, Electrochemical Mediators, Screen-Printed Electrodes (how to use, fabricate and modify them), Sensors and Biosensors modified with Nanomaterials (carbon black, gold nanoparticles, etc.), Paper based (bio)sensors. Real applications in the field of clinical, food and environmental analytical chemistry. She received Best Young Researcher Award from the Analytical Chemistry Division of the Italian Chemical Society on 2013.
The research activity carried out was published in 65 articles (9 reviews) in ISI peer-reviewed journals, among them with high impact factor in the analytical chemistry journal (e.g. Biosensor and Bioelectronics IF 8.173), 12 chapters in books, 5 proceedings. 22 articles as first-author + 36 articles as corresponding author + 4 articles as co-corresponding author, 1 patent. H-index: 32, with 2588 total citations (Scopus, Jan 2019). She is author of more than 100 presentations at National and International congress, including several invited plenary and keynotes.

Danila Moscone is Full Professor in Analytical Chemistry at the Department of Chemical Science and Technologies, University of Rome Tor Vergata. Research Activity: 33 chapters on books, 183 papers on international and national scientific journals, 4 patents, 36 proceedings, 2 videos, more than 300 oral and poster presentations at scientific meetings. H-index 45, and 5982 citations (Scopus, May 2019).
Responsible of projects funded by CNR on Biotechnology, by the Ministero della Salute, Ministero degli Esteri and by MIUR (COFIN 2003, PRIN 2005, 2007, 2009, 2015, 2017) and by private companies (Menarini Diagnostic Division, since 2003, Radim, Etatron). She is Editor of Biosensors and Bioelectronics, the principal international journal devoted to research, design, development and application of biosensors and bioelectronics, and member of the Editorial Board of Biosensors, MDPI since 2017, editor of a special issue of Sensors titled “Paper-based sensors” and Reviewer for 30 International scientific journals.

Veronica Caratelli is first-year PhD student in Chemical Science at Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, Italy. In the same University, she received her master degree in Biotechnology on 16th May 2018 with final grade of 110/110. Since her master’s degree thesis, her research activity deals with the development of sustainable and eco-friendly paper-based printed electrochemical biosensors for environmental analysis (main target analytes: pesticides such as organophosphorus compounds) and for precision medicine (i.e. Alzheimer’s diseases, Pancreatic cancer). She also exploits the properties of nanomaterials (i.e. carbon black, Prussian blue and gold nanoparticles) to increase the electroanalytical performances of sensors. Currently, she is author of two published paper in the peer-reviewed journal Biosensor and Bioelectronics (IF 8.173).


Noemi Colozza is a postdoctoral researcher at the NanoBioSensing Lab in the Department of Chemical Science and Technologies of the University of Rome "Tor Vergata" (Italy). In the same University, she received her master degree in Chemistry on 29th May 2015 with full marks and honours, and afterwards her doctorate in Chemistry on 28th February 2019. Her research activity deals with the development and characterisation of sustainable and user-friendly printed electrochemical (bio)sensors for the environmental and security field. Her main studies have focused on voltammetric detection of heavy metals, (bio)remediation of heavy metal polluted environment, and enzyme-based amperometric detection of chemical weapon mustard agents. These objectives have been reached through the development of (bio)sensors screen-printed on several materials (polyester, office paper, filter paper) eventually modified with different nanomaterials (carbon black, Prussian blue, gold nanoparticles) and biological components (enzymes). Very recently, she developed potentiometric paper-based screen-printed electrodes for monitoring the state of conservation of reinforced concrete.
Her work was awarded with the 2019 PhD prize from the Electrochemical Division of the Italian Chemical Society. She is co-author of 7 published papers in peer-reviewed journals (e.g. Biosensor and Bioelectronics IF 8.173), and 10 presentations at National and International congresses.

Vincenzo Mazzaracchio is PhD student at Department of Chemical Science and Technologies, University of Rome "Tor Vergata", Italy. He graduated on 2016 in Chemistry at the same University. His research activity is focused on sensors and biosensors developing for analytical application in the field of clinic, food and environment. During the years he obtained specific knowledge on electrochemical techniques (i.e. impedance spectroscopy, amperometry, cyclic voltammetry and potentiometry), for heavy metals, inorganic pollutants and bacteriological species detection in water samples and ions detection in biological fluid. Moreover, he earned important skills on the use of nanomaterials (i.e. Carbon Black, gold nanoparticles, etc.), the screen-printing technology for miniaturized electrode fabrication onto plastic and paper substrate, the use of 3D printers for the realization of nanosized and high-resolution object for analytical support.

Marcoccio Eleonora is a master student in chemistry at University of Rome Tor Vergata. She is involved in the development of an electrochemical sensor for the automated determination of Salmonella taking part within SCIADRO project in collaboration with INSTM. Being interested in sustainability, she won the third prize presenting paper based sensors to monitor food safety at “Lavazza and Youth for SDGs” and "UrbanFarm2019" contests, and attended the “Sustainable Development Labs” Multidisciplinary Summer School of the University of Rome Tor Vergata and "The 2030 Agenda and the sustainable development goals" course held by ASVIS


Stand A21 (pav. 7) - Università degli Studi di Roma "Tor Vergata"

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